Mitochondria: The Next (Neurode) Generation
Adult-onset neurodegenerative disorders are disabling and often fatal diseases of the nervous system whose underlying mechanisms of cell death remain unknown.
Defects in mitochondrial respiration had previously been proposed to contribute to the occurrence of many, if not all, of the most common neurodegenerative disorders. However, the discovery of genes mutated in hereditary forms of these enigmatic diseases has additionally suggested defects in mitochondrial dynamics. Such disturbances can lead to changes in mitochondrial trafficking, in interorganellar communication, and in mitochondrial quality control. These new mechanisms by which mitochondria may also be linked to neurodegeneration will likely have far-reaching implications for our understanding of the pathophysiology and treatment of adult-onset neurodegenerative disorders.
To learn more about Mitochondria and Chronic Diseases, please find more information on www.targeting-mitochondria.com , the official website of the 2nd World Congress on Targeting Mitochondria 2011, which will be held in Berlin in October 20-21,
Source: Mitochondria: The Next (Neurode) Generation - Eric A. Schon, Serge Przedborski ; Neuron, Volume 70, Issue 6, 1033-1053, 10.1016/j.neuron.2011.06.003
