Cellomics of mitochondrial morphofunction: presentation of the recent advances


During the 9th World Congress on Targeting Mitochondria 2018 which will be held in Berlin next October 23-25, Prof. Werner Koopman from RadboudUMC University, Nijmegen, The Netherlands will present a strategic talk about Cellomics of mitochondrial morphofunction.

According to Prof Koopman: "Mutations in NADH:ubiquinone oxidoreductase (complex I or CI), the first complex of the mitochondrial oxidative phosphorylation (OXPHOS) system, induce Leigh syndrome (LS) leading to early death in children. The LS pathomechanism is still poorly understood and effective treatment options are still lacking. Here we applied high content microscopy analysis (cellomics) to investigate the hypothesis that LS fibroblasts display “reductive stress” and that this stress impacts on cell viability and bioenergetics."

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