Targeting the mitochondria shaping protein Opa1 to inhibit angiogenesis

Luca Scorrano Targeting Mitochondria 2018 speaker

During the next 9th World Congress on Targeting Mitochondria on October 23-25, 2018, Prof. Luca Scorrano will give a presentation about : “Targeting the mitochondria shaping protein Opa1 to inhibit angiogenesis”

When we ask the professor from the University of Padova in Italy, to talk a little about his future presentation, he respond:
“The role of mitochondrial dynamics in angiogenesis, the physiological process through which new blood vessels form from pre-existing ones, has not been addressed. We will present data showing that Opa1 is a crucial component of the angiogenetic program. Upon endothelial cells angiogenic stimulation, mitochondria elongate and Opa1 level increases. Genetic Opa1 ablation signals retrogradely from mitochondria to the nucleus to modify angiogenic genes expression and therefore inhibits all features of angiogenesis. Conditional Opa1 ablation substantiates its role in mouse and zebrafish angiogenesis and in lymphangiogenesis-mediated tumor metastatization. Thus, Opa1-dependent mitochondrial dynamics is a targetable component of angiogenesis”.


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Targeting Mitochondria 2018
October 23-25, 2018 - Berlin, Germany