Dysregulation of Mitochondria-Lysosome Contacts by GBA1 Dysfunction in Dopaminergic Neuronal Models of Parkinson’s Disease
Dr. Dimitri Krainc, from the Northwestern University Feinberg School of Medicine, Chicago in USA will be will be joining the Targeting Mitochondria 2021 Congress and will demonstrate his study regarding the "Dysregulation of Mitochondria-Lysosome Contacts by GBA1 Dysfunction in Dopaminergic Neuronal Models of Parkinson’s Disease".
Dr. Krainc confirms that he recently identified the formation of direct mitochondria-lysosome membrane contacts that mark sites for lysosomal regulation of mitochondrial networks. However, mitochondrial contacts regulate lysosomal dynamics providing a new angle to studies of these organelles in neurodegenerative diseases.
Targeting Mitochondria 2021 Congress
October 27-29, 2021 - Berlin & Virtual Congress
www.targeting-mitochondria.com
Introduction Remarks: Past, Present and Future
Dr. Egbert Mik, from University Medical Center Rotterdam, The Netherlands, will join the 12th Targeting Mitochondria Congress in October 2021, to give a talk entitled "Introduction Remarks: Past, Present and Future".
During the sessin, Dr. Mik will explain the challenge of qualitative and quantitative assessment of mitochondrial function in vitro and in vivo, as well as future perspectives regarding this subject.
Targeting Mitochondria 2021 Congress
October 27-29, 2021 - Berlin & Virtual Congress
www.targeting-mitochondria.com
A Potential Mitochondrial Link Between Life Stress and the Reversibility of Hair Greying in Humans
Dr. Martin Picard, Associate professor of behavioral medicine at Columbia University Vagelos College of Physicians and Surgeons, USA will be joining the Targeting Mitochondria 2021 Congress and give a presentation entitled "A Potential Mitochondrial Link Between Life Stress and the Reversibility of Hair Greying in Humans".
Life stress causes neuroendocrine and metabolic alterations that influence mitochondria; and in turn, mitochondria produce signals and energy that influence pigment production that color our hairs. This presentation will describe a new approach to quantify human hair pigmentation patterns, demonstrating that human hair graying is rapidly reversible and linked to life stress. Individual hairs transitioning from their young-dark to old-white states, and reverting back to dark, show specific mitochondrial proteomic recalibrations pointing to a threshold-based metabolic mechanism for hair greying.
Targeting Mitochondria 2021 Congress
October 27-29, 2021 - Berlin & Virtual Congress
www.targeting-mitochondria.com
Optimization of Energy Homeostasis in Old Age by SIRT6
Prof. Haim Cohen, head of the Molecular Mechanism of Aging Laboratory at Bar-Ilan University, Israel will be joining the Targeting Mitochondria 2021 Congress and give a presentation entitled "Optimization of Energy Homeostasis in Old Age by SIRT6".
Prof. Cohen's Studies in model organisms showed that the activity of the Sir2 family of NAD+-dependent protein deacetylases (sirtuins) is important in regulating lifespan in yeast, worms, and flies. He shows that overexpression of mammalian sirtuin SIRT6 in mice leads to a reduction in frailty and lifespan extension by ~30%. To do so, SIRT6 restores energy homeostasis of old animals through an improvement in the utilization of two major gluconeogenic precursors, lactate and glycerol.
Targeting Mitochondria 2021 Congress
October 27-29, 2021 - Berlin & Virtual Congress
www.targeting-mitochondria.com
Nuclear Sensing of Breaks in Mitochondrial DNA Enhances Immune Surveillance
Dr. Agnel Sfeir from Memorial Sloan Kettering Cancer Center, USA, will give a presentation on :Nuclear Sensing of Breaks in Mitochondrial DNA Enhances Immune Surveillance"
Dr. Sfeir will describe mitochondrial DNA double-strand breaks (mtDSBs) as toxic lesions that compromise the integrity of mitochondrial DNA (mtDNA) and alter mitochondrial function. Communication between mitochondria and the nucleus is essential to maintain cellular homeostasis; however, the nuclear response to mtDSBs remains unknown. Here, using mitochondrial-targeted transcription activator-like effector nucleases (TALENs), we show that mtDSBs activate a type-I interferon response that involves the phosphorylation of STAT1 and activation of interferon-stimulated genes. After the formation of breaks in the mtDNA, herniation mediated by BAX and BAK releases mitochondrial RNA into the cytoplasm and triggers a RIG-I-MAVS-dependent immune response. We further investigated the effect of mtDSBs on interferon signalling after treatment with ionizing radiation and found a reduction in the activation of interferon-stimulated genes when cells that lack mtDNA are exposed to gamma irradiation. We also show that mtDNA breaks synergize with nuclear DNA damage to mount a robust cellular immune response. Taken together, we conclude that cytoplasmic accumulation of mitochondrial RNA is an intrinsic immune surveillance mechanism for cells to cope with mtDSBs, including breaks produced by genotoxic agents.
Targeting Mitochondria 2021 Congress
October 27-29, 2021 - Berlin & Virtual Congress
www.targeting-mitochondria.com
Impact of Mitochondrial Dynamics on Stem Cell Function: Insights from Physiology, Diseases and Aging
Dr. Mireille Khacho, from Faculty of Medicine, University of Ottawa, Canada will be joining the Targeting Mitochondria 2021 World Congress, which will be held October 27-29, 2021 and will present her study on "The Impact of Mitochondrial Dynamics on Stem Cell Function: Insights from Physiology, Diseases and Aging".
Targeting Mitochondria 2021 Congress
October 27-29, 2021 - Berlin & Virtual Congress
www.targeting-mitochondria.com
Age-Related Mitochondrial Dysfunction as a Key Factor in COVID-19 Disease
Dr. Guillermo López-Lluch from Universidad Pablo de Olavide-CSIC, Spain will be joining the Targeting Mitochondria 2021 World Congress, which will be held October 27-29, 2021 and give a presentation on Age-related Mitochondrial Dysfunction as a Key Factor in COVID-19 Disease.
Dr. Lluch states that COVID-19 and other respiratory diseases induce an inflammatory response mainly produced by the release of inflammatory cytokines. In this response, lymphocyte release of interferon decrease impairing the immune response against virus infection. In both, inflammatory response and inhibition of interferon release, activity of mitochondria plays a key role. Accumulation of dysfunctional mitochondria during aging and chronic metabolic diseases can be the key of the inefficient response against respiratory infections.
Targeting Mitochondria 2021 Congress
October 27-29, 2021 - Berlin & Virtual Congress
www.targeting-mitochondria.com
Clinical Application of Antioxidants to Improve Human Oocyte Mitochondrial Function: Advances and Perspective
Dr. Cristina Rodríguez-Varela from Medical Research Institute Hospital La Fe (IIS La Fe) in Valencia, Spain will give a presentation on Clinical Application of Antioxidants to Improve Human Oocyte Mitochondrial Function: Advances and Perspective.
Dr. Rodríguez-Varela will discuss the fact that mitochondria are essential organelles in the acquisition of human oocyte competence, as sufficient energy levels are crucial for optimal oocyte maturation, fertilization and subsequent embryo development. In addition, mitochondria constitute the first antioxidant line of defense within the cell, counteracting reactive oxygen species (ROS) derived from its own metabolism. An imbalance between the amount of ROS produced and the capacity of the cell to counteract them leads to oxidative stress, and ultimately to mitochondrial dysfunction. This dysfunction, in turn, impairs cellular functions through reduced ATP output and/or increased oxidative stress. Hence, oxidative stress may be the cause of, or be caused by, mitochondrial dysfunction. Regardless of the origin, this condition gives rise to a vicious cycle with positive feedback, ultimately compromising the overall oocyte quality. Antioxidant therapy has arisen in this context as a new approach aiming to improve human oocyte quality by means of improving, or just protecting, mitochondrial function. In this talk, we will highlight the importance of optimal levels of functional mitochondria in the acquisition of human oocyte competence, and we will give an overview of the main antioxidant supplementation therapies currently under research in our species.
Targeting Mitochondria 2021 Congress
October 27-29, 2021 - Berlin & Virtual Congress
www.targeting-mitochondria.com
Extracellular Mitochondria for Therapy and Diagnosis in Stroke
Dr. Kazuhide Hayakawa, Assistant Professor at Harvard Medical School/ Massachusetts General Hospital, USA will join the Targeting Mitochondria 2021 congress which will be held on October 27-29, 2021 and give a presentation entitle "Extracellular Mitochondria for Therapy and Diagnosis in Stroke".
Recent accumulating findings in cell were provided by Dr. Hayakawa, as well as in animals and humans. These studies suggest that mitochondria maybe surprisingly present in extracellular space andregulatea non-cell-autonomous mechanism in the CNS by mediating injury and recovery. Given that extracellular mitochondria are passively secreted by damaged cells or released from activated cells, it may allow us to look into the metabolic status to diagnose overall disease severity or progress of repair. Moreover, exogenous mitochondrial transplantation may protect neurons in acute CNS injury. Further studies are warranted to carefully assess whether extracellular mitochondria serve as a novel class of biomarkers and whether the putative transfer of mitochondria between cells in the CNS can be leveraged to augment recovery after stroke or neurodegenerative diseases.
Targeting Mitochondria 2021 Congress
October 27-29, 2021 - Berlin & Virtual Congress
www.targeting-mitochondria.com
Big Change from Small Player - Mitochondria Alter Body Metabolism and Gene Expression
Prof. Scott Ballinger from University of Alabama at Birmingham, USA will be joining the Targeting Mitochondria 2021 World Congress, which will be held October 27-29, 2021 and give a presentation on "Big Change from Small Player - Mitochondria Alter Body Metabolism and Gene Expression".
Targeting Mitochondria 2021 Congress
October 27-29, 2021 - Berlin & Virtual Congress
www.targeting-mitochondria.com
Mitochondrial Transplantation Therapy, the Recent Advances and Perspective
Dr. James McCully, from the Harvard Medical School Department of Cardiac Surgery Boston Children’s Hospital, USA, will be joining the Targeting Mitochondria 2021 World Congress, which will be held October 27-29, 2021.
Dr. McCully will present his recent study on "Mitochondrial Transplantation Therapy, the Recent Advances and Perspective" during the congress.
Dr. McCully’s research focuses on the mechanisms and subcellular localization of the biochemical and molecular events contributing to myocardial cell death. In particular, his lab has investigated the discriminant and/or coordinate mechanisms leading to ischemia/reperfusion injury in the neonate, child, mature and aged male and female with particular emphasis on the development of novel and specific cardioprotective protocols.
Recently he has developed a novel approach to cardioprotection using autologous mitochondrial transplantation. His research has demonstrated that transplantation of autogeneic mitochondria into the ischemic zone of the myocardium during early reperfusion significantly enhances post-ischemic functional recovery.
Targeting Mitochondria 2021 Congress
October 27-29, 2021 - Berlin & Virtual Congress
www.targeting-mitochondria.com
Regulation of Physiological Mitophagy
Prof. Thomas G. McWilliams from University of Helsinki, Finland will join the Targeting Mitochondria 2021 congress and will present his research on "Regulation of Physiological Mitophagy".
Key Publications
McWilliams TG*,Prescott AR, Montava-Garriga L, Brooks SP, Singh F, Barini E, Muqit MM and Ganley IG*(2018a)
Basal mitophagy occurs independently of PINK1 in mouse tissues of high-metabolic demand. Cell Metabolism Feb 06; 27(2): 439-449.
McWilliams TG* et al., (+28 Authors) Ganley IG, Suomalainen A, Muqit MMK*(2018b).
Phosphorylation of Parkin at Serine65 is essential for its activation in vivo.
Open Biology. Nov8:180108.
Suomi F & McWilliams TG*(2019)
Autophagy in the nervous system: a primer for neuroscientists.
Neuronal Signaling 3 (3): NS20180134.
Targeting Mitochondria 2021 Congress
October 27-29, 2021 - Berlin & Virtual Congress
www.targeting-mitochondria.com
Mechanism of Membrane-Tethered Mitochondrial Protein Synthesis
Dr. Antoni Barrientos from University of Miami Miller School of Medicine, USA will give a presentation entitled "Mechanism of Membrane-Tethered Mitochondrial Protein Synthesis".
The main research interest of their laboratory is on the basic mechanisms that govern the biogenesis of mitochondrial protein complexes in health, disease and aging. They are most specifically interested in the assembly and function of the mitochondrial translation machinery and of the mitochondrial respiratory chain and oxidative phosphorylation system components, involved in biological energy transduction.
The study of mitochondria is now a very “hot issue” for both basic and clinical research. Mitochondria are not only the “energy factories” of the cell but they also house a multiplicity of pathways that serve to regulate cellular life and death. Importantly, mitochondria are involved in prevalent human diseases of wide social impact, most notably neurodegenerative disorders, but also in cancer and the aging process.
Targeting Mitochondria 2021 Congress
October 27-29, 2021 - Berlin & Online
www.targeting-mitochondria.com
Cardiorespiratory Fitness and Mitochondrial Health as Modulators of COVID-19
Dr. Johannes Burtscher, from University of Lausanne, Suisse will join the Targeting Mitochondria 2021 Congress and will give a presentation entitled "Cardiorespiratory Fitness and Mitochondrial Health as Modulators of COVID-19".
Dr. Burtscher confirms that some coronaviruses like SARS-CoV-2, the pathogen causing COVID-19, manipulate host cell mitochondria to dodge the host immune defense. We hypothesize that good mitochondrial health, for example due to regular exercise and associated with cardiorespiratory fitness, protects from viral manipulation of mitochondria. Conversely, mitochondrial damage may facilitate viral infection and aggravate the disease. I will summarize the theoretical interactions of SARS-CoV-2 with host mitochondria and provide an overview of recent studies investigating the link between COVID-19 and cardiorespiratory fitness and mitochondrial health.
Targeting Mitochondria 2021 Congress
October 27-29, 2021 - Berlin & Virtual Congress
www.targeting-mitochondria.com
Mitochondrial Arginase-2 is Essential for IL-10 Metabolic Reprogramming of Inflammatory Macrophages
Dr. Claire McCoy from Royal College of Surgeons in Ireland, Ireland will join the Targeting Mitochondria 2021 Congress and give a presentation about "Mitochondrial Arginase-2 is Essential for IL-10 Metabolic Reprogramming of Inflammatory Macrophages".
Dr. Claire McCoy graduated in Biochemistry from Trinity College Dublin and completed her PhD at the University of Dundee, Scotland in 2006. Her first postdoctoral position in Innate Immunology was completed at Trinity College Dublin, during which time she was awarded a prestigious Marie Curie International Fellowship. She joined the Hudson Institute, Melbourne as a Research Fellow in 2010 and obtained a New Investigator Project Grant from the NHMRC to continue her work investigating the role of microRNAs in Inflammatory diseases. Claire joined RCSI as the Immunology lecturer in August 2016, where she now leads the growing microRNA Inflammation research group. Claire was the recipient of an SFI Future Research Leader's award presented by President Higgins in January 2018.
Targeting Mitochondria 2021 Congress
October 27-29, 2021 - Berlin & Virtual Congress
www.targeting-mitochondria.com
More Articles...
- A session dedicated to Nuclear-mitochondrial interactions and their effect on longevity and health will be organized
- Deciphering strategic interactions between mitochondrial and nuclear genome
- Circulating Mitochondrial DNA as an Early Indicator of Severe Lung Disease
- The Bioenergetics Consequences of Winter Cold in Small Birds
