Hydrogen sulfide and mitochondrial function: Presentation of the scientific advances

MarkusDuring the 8th World Congress on Targeting Mitochondria 2017, Dr. Csaba Szabo from University of Texas, USA will present his work on "Hydrogen sulfide and mitochondrial function".

According to him: "H2S has emerged over the last decade as an important, endogenously produced biological mediator. Inhibition of cytochrome C oxidase is the longest known mitochondrial effect of H2S. However, work of recent years showed that H2S, at lower concentrations, acts as an electron donor to the mitochondria, and serves as an inorganic substrate for mitochondrial electron transport. Additional mitochondrial effects of H2S include the stimulation of mitochondrial electron transport via inhibition of mitochondrial phosphodiesterase 2A, and activation of Complex V via sulfhydration. In some disease conditions (e.g. ischemia, vascular disease, diabetic complications), H2S levels are decreasing and H2S donation can exert therapeutic effects. In other conditions, the idea that H2S can be used to induce an on-demand metabolic suppression ("hibernation") has been proposed. In yet other conditions (e.g. inflammation, septic shock, burn injury and certain forms of cancer), H2S overproduction occurs and H2S biosynthesis inhibitors may be a therapeutic approach of the future. The talk will overview the various mitochondrial actions of H2S and will highlight some of the physiological, pathophysiological and therapeutic implications of these processes."

More information: www.targeting-mitochondria.com

How to regulate cardiac excitation-contraction-bioenergetics coupling by mitochondrial fission protein Drp1?

Shey-Shing Sheu

"Studies have shown that Drp1 is abundantly expressed in adult cardiac myocytes. Paradoxically, compared to numerous cell types, adult cardiac myocytes exhibit very low frequency in mitochondrial fission. In this presentation, I will describe the mechanisms of non-canonical (fission-independent) roles of Drp1 in regulating cardiac bioenergetics during the heartbeats."

Prof Shey-Shing Sheu from Thomas Jefferson University, USA will talk about the regulation of cardiac excitation-contraction-bioenergetics during Targeting Mitochondria 2017 world congress which will be held in Berlin, Germany.

More information: www.targeting-mitochondria.com

 

Creation of a designer molecule to target and silence mitochondrial gene transcription

Ganesh Pandian NAMASIVAYAM - Targeting Mitochondria 2017  -v1

Dr. Ganesh Pandian Namasivayam from Kyoto University, Japan will present his research on "Creation of a designer molecule to target and silence mitochondrial gene transcription'' during Targeting Mitochondria 2018 congress.

According to Dr Namasivayam: "Harnessing the sequence information about the mitochondrial gene transcription, we created a synthetic designer molecule termed MITO-PIP that can selectively localize inside mitochondrion and recognize the target DNA sequence. MITO-PIP triggered targeted transcriptional suppression in HeLa cells by inhibiting the mitochondrial transcription factor A to the light-strand promoter. Currently, we are advancing our designer molecule to gain control over mitochondrial gene expression."

For more information, please visit www.targeting-mitochondria.com

 

 

 

 

Mitochondrial dysfunction play a key role in the pathophysiology of Alzheimer Disease

Natalia stefanova targeting mitochondriaDr Natalia Stefanova, from the Institute of Cytology and Genetics, Novosibirsk, Russia will tell about their recent experimental research that support that mitochondrial dysfunction play a key role in the pathophysiology of Alzheimer Disease (AD) and that therapies with target mitochondria are potent to normalize a wide range of cellular signaling processes and therefore slow the progression of AD. She studied the role of mitochondria in the pathophysiology of this disorder using OXYS rats that simulate key characteristics of sporadic AD. It was shown that treatment with mitochondria-targeted SkQ1 via improvement of structural and functional state of mitochondria is able to alleviated the structural neurodegenerative alterations, prevented the neuronal loss and synaptic damage, increased the levels of synaptic proteins, enhanced neurotrophic supply, and decreased amyloid-β1-42 protein levels and tau hyperphosphorylation in the hippocampus of OXYS rats, resulting in improvement of the learning ability and memory.

 

More information: www.targeting-mitochondria.com

Mitochondrial ROS and longevity: Recent scientific advances

Anne Lechuga V Targeting mitochondriaAna Lechuga-Vieco, researcher from Fundación Centro Nacional de Investigaciones Cardiovasculares, Spain will talk about her study on "Mitochondrial ROS and longevity: Recent scientific advances" during 8th World congress on Targeting Mitochondria.

According her reseach, she summarize her talk: "Animal models with identical nuclear genomes but with different mtDNA haplotypes (conplastic mice) generate functionally different OXPHOS systems that shape the organismal metabolism, supporting the conclusion that different mtDNA wild type haplotypes are phenotypically relevant. We report that mtDNA haplotype profoundly influences reactive oxygen species generation, energy homeostasis metabolism, and ageing parameters among others, resulting in different healthy longevities of conplastic strains. The existence of intrinsic mismatch between mtDNA and nDNA reveals lifelong metabolic consequences."

 

For more information, please visit www.targeting-mitochondria.com

 

Dr Yuri Takeda will talk about the prevention of mitochondrial disease transmission

Yuko Takeda Targeting mitochondriaDr. Yuko Takeda from The Newcastle University, United Kingdom will participate to the Targeting Mitochondria World congress 2017 and present her & her team's study on "Early pronuclear transfer to prevent mitochondrial DNA disease".

According to Dr Takeda, the mutations in mitochondrial DNA (mtDNA) are maternally transmitted and are associated with a broad range of debilitating and fatal multisystem diseases. There are currently no effective treatments for mtDNA disease, however, there has been much interest in the potential of reproductive technologies to prevent transmission. One approach involves the transfer of pronuclei from the fertilized egg of an affected woman to that of a healthy donor, termed pronuclear transfer (PNT).

More information about the congress: www.targeting-mitochondria.com

 

iPSC-based drug discovery for neurological mitochondrial disease: presentation of recent scientific data

Alessandro Prigione Targeting Mitochondria

Mitochondrial DNA (mtDNA) mutations frequently cause neurological diseases. Modeling of these defects has been difficult because of the challenges associated with engineering mtDNA. Patient-derived induced pluripotent stem cells (iPSCs) allow the development of innovative cellular models in a personalized approach.

During Targeting Mitochondria World Congress, Dr Alessandro Prigione from Max Delbrueck Center for Molecular Medicine, Germany will discuss the potential benefits of patient iPSCs for drug discovery of neurological mitochondrial diseases.

To access to the preliminary agenda, please click here.

What is the impact of mitochondria-targeted antioxidants on cancer progression?

Martin Bergo Targeting MitochondriaROS can be produced at different sites in cells: it can be formed in the plasma membrane, the cytosol, but the main ROS generator is the electron transport chain (ETC) located in the mitochondrial matrix. Interestingly, enhanced or disrupted mitochondrial activity can increase superoxide production within the mitochondria of cancer cells. The increased superoxide production has been associated with cell survival and metastasis. Thus, it has been hypothesized that specifically targeting mitochondrially-produced ROS could reduce the survival and invasive abilities of cancer cells. Consequently, several mitochondrial antioxidants have been developed and tested; but thus far, no studies have defined the impact of mitochondria-targeted antioxidants on the progression of cancer in endogenous mouse models.

In this talk, Pr Martin Bergö from Sahlgrenska Cancer Center, Sweden, will give an update of their experiments designed to address this issue.

For more information about Targeting Mitochondria Congress: www.targeting-mitochondria.com

 

Self-Assembled Polymeric Nanoparticle for Mitochondria-Targeting Drug Delivery

targeting mitochondria HC kANGDr Han Chang Kang, from the Department of Pharmacy, The Catholic University of Korea, Republic of Korea will present his recent research about the Self-Assembled Polymeric Nanoparticle for Mitochondria-Targeting Drug Delivery.

Recently, subcellular targeting drug delivery systems that specifically reach subcellular compartments (e.g., cytosol, nucleus, and mitochondria) of interest have garnered more attention because their action sites for generating therapeutic effects occur not just at the cellular level but at the subcellular level as well. Among them, this presentation will be focused on mitochondria-targeting self-assembled polymer-based nanoparticles for intracellular drug delivery because mitochondria are very significant intracellular organelles for controlling the homeostasis of vital physiological functions and synthesizing bioenergy molecules and their dysfunction leads to a variety of human disorders including neurodegenerative, neuromuscular, cardiac, and metabolic diseases. The significance of the mitochondria in disease allows a broad spectrum of therapeutics to strengthen or weaken their intrinsic or newly-introducing functions. Thus, the presentation will introduce the mitochondria-targeting drug delivery systems designed by me and my collaborators. 

For more information about Targeting Mitochondria Congress: www.targeting-mitochondria.com

 

Presentation of the mitochondrial DNA damaged induced inflammation in lung epithelial cells

Bartosz Szczesny Targeting Mitochondria

Dr Bartosz Szczesny, Associate Professor at the Department of Anesthesiology of the University of Texas Medical Branch at Galveston, USA is invited during Targeting Mitochondria World Congress is to give a presentation about the mitochondrial DNA damaged induced inflammation in lung epithelial cells.

According to Dr Szczesny: "Pulmonary epithelial cells are key effectors and targets in the pathogenesis of inflammatory lung diseases such as asthma, and chronic obstructive pulmonary disease, among others. Oxidative stress has been implicated at the earliest step in development of lung inflammation, but the molecular mechanisms of how oxidantive injury to epithelial cells develops inflammatory response remain unclear. While investigating the mechanisms responsible for activating inflammation in response to prolonged, low-level oxidative stress, we identified a role for an active and selective cellular extrusion of damaged mitochondrial DNA, that did not affect cellular viability. Selective release of damaged mitochondrial DNA, first into the cytoplasm and subsequently into the extracellular space, triggers autocrine and paracrine modes of the inflammatory response. I will be discussing cellular outcomes and inflammatory signaling pathways in response to mitochondrial DNA-specific damage in cell culture and in vivo models."

More information about the congress: www.targeting-mitochondria.com

 

The registrations for Targeting Mitochondria 2017 World Congress are now open!

Brandenburg-Gate-West-Berlin

On behalf of the Scientific Committee of World Mitochondria Society, we are pleased to inform you that the 8th World Congress on Targeting Mitochondria will be organized on October 23 and 24, 2017 at Steigenberger Hotel, in Berlin.

You can now register to the congress with the very early bird rates before March 21, at midnight, by clicking here.

You can also submit your abstract until September 14 for short oral presentation and until September 28 for poster presentation here.

We look forward to meeting you in Berlin next October.

World Mitochondria Society
www.targeting-mitochondria.com

 

Pr Marvin Edeas and Pr Volkmar Weissig commented the 7th World Congress on Targeting Mitochondria 2016

Marvin Edeas and Volkmar Weissig Targeting Mitochondria

The 7th World Congress on Targeting Mitochondria was organized in Berlin on October 24-26, 2016. This seventh edition was again a huge success and gathered more than 350 attendees, academics, industrials and start-ups during three days, representing more than 27 countries.

The scientific committee validated more than 170 communications (oral and poster) which have highlighted the recent scientic advances on mitochondria and all related researches such as the methods to evaluate mitochondria function/dysfunction, but also new strategies to target the mitochondria. To access to the final program of the congress, please follow this link.

Pr Volkmar Weissig, from the Midwestern University commented: “As President of the WMS I am extremely happy about the success of our 7th World Conference on Targeting Mitochondria. I would like to personally thank the organizing team for the excellent work they have done in planning and setting up this conference. Of course, any conference is just as good as its participants. Therefore I sincerely thank all invited speakers, all presenters of short oral communications and all poster presenters for their excellent contributions. I also would like to thank all other attendees for participating in our conference. Our conference series has over the last years significantly grown with respect to the number of registrations. With over 310 participants from almost all continents we have set a new a record. I believe our conference series has established itself as a major event in the international “mitochondrial landscape”. If I may say so, mitochondria have found a home in Berlin! With excitement I am already looking forward to the 8th edition next year and I sincerely hope to see most if not all of you again one year from now.”

From his side, Pr Marvin Edeas, from Institut Cochin, INSERM U1016, University Paris Descartes commented: "The world of mitochondria is "hyper-dynamic". Mitochondria is a very dynamic organelle, it moves, oscillates and communicates with cells and in particular with microbiota. We need to re-design a "dynamic" strategy to target mitochondria in all its dimensions. This strategy must integrate all factors and actors (microbiota).
Again, as founder of WMS and co-chairman of the scientific committee, I believe that mitochondria-microbiota inter-talk is one of the perfect target to highlight."

To conclude this three-day meeting, the scientific awarded two scientists for their research:

Daniel Schniertshauer from the Albstadt-Sigmaringen University of Applied Sciences, Germany for his poster presentation about "Accelerated Regeneration of ATP Level after Irradiation in Human Skin Fibroblasts by Coenzyme Q10". 

For more information about this award, please click here.

François Mouton-Liger from the ICM - Brain & Spine Institute, France for his short oral presentation about "Role of Parkin in innate immunity: crosstalk between mitochondrial dysfunction and NLRP3 inflammasome signaling".

For more information about this award, please click here.

The dates of Targeting Mitochondria 2017 will be announced very soon on the website.

World Mitochondria Society
www.targeting-mitochondria.com

 

The award for the short oral presentation was discerned to François Mouton-Liger

At the end of Targeting Mitochondria World Congress, Pr Volkmar Weissig and Pr Marvin Edeas awarded two scientists for their research. Among them:

Francois-Mouton-Liger Award Targeting Mitochondria 2016

François Mouton-Liger from the ICM - Brain & Spine Institute, France for his short oral presentation about "Role of Parkin in innate immunity: crosstalk between mitochondrial dysfunction and NLRP3 inflammasome signaling".

 

 

Testimonial by Dr Mouton-Liger: "Understanding mechanisms by which mitochondrial dysfunction contributes to the pathophysiological processes of neurodegenerative disorder, in particular Parkinson disease, will need in the future an integrated vision of all mitochondrial aspects from emerging methods to evaluate mitochondria function to new molecular interactions link to this organelle. By this way, the 7th World Congress on Targeting Mitochondria was, for me, a huge success by connecting remarkable researchers from such different area of the field, For these reasons, it will be a great pleasure for me to participate to this conference next year."

 

The second award was discerned to Daniel Schniertshauer from the Albstadt-Sigmaringen University of Applied Sciences, Germany for his poster presentation about "Accelerated Regeneration of ATP Level after Irradiation in Human Skin Fibroblasts by Coenzyme Q10". 

For more information about this award, please click here.

World Mitochondria Society

Daniel Schniertshauer was awarded for his poster presentation during Targeting Mitochondria 2016

At the end of Targeting Mitochondria World Congress, Pr Volkmar Weissig and Pr Marvin Edeas awarded two scientists for their research. Among them:

Daniel Schniertshauer Award Targeting Mitochondria 2016

Daniel Schniertshauer from the Albstadt-Sigmaringen University of Applied Sciences, Germany for his poster presentation about "Accelerated Regeneration of ATP Level after Irradiation in Human Skin Fibroblasts by Coenzyme Q10". You can download his poster by clicking here.

 

 

Testimonial by Dr Schniertshauer: "The 7th World Congress on Targeting Mitochondria was the second time I was allowed to attend this conference after 2015. The participation of several hundred participants from all over the world at the last congress showed me the importance of this event in the research community of mitochondria. As last year, I was already looking forward to the most diverse presentations, the nice conversations with colleagues and the establishment of contacts between the lectures. In addition, the daily poster sessions were excellent for picking up the one or the other piece of advice from experienced colleagues.
It was inspiring to see how researchers with a wide range of topics are interested in the current research, exploring them and are interested in the contributions of the other presenters. For me this was living science!
I think, not only for young doctoral students, the visit of such a congress is highly recommended, because through the diversity of topics you get insights into other areas of mitochondrial research and thus you can look beyond the box. The aim of such an event should be to make the knowledge of current themed lectures tangible for your own research. I'm really looking forward to the next Targeting Mitochondria."

 

 

Francois-Mouton-Liger Award Targeting Mitochondria 2016

François Mouton-Liger from the ICM - Brain & Spine Institute, France for his short oral presentation about "Role of Parkin in innate immunity: crosstalk between mitochondrial dysfunction and NLRP3 inflammasome signaling".

 

Testimonial by Dr Mouton-Liger: "Understanding mechanisms by which mitochondrial dysfunction contributes to the pathophysiological processes of neurodegenerative disorder, in particular Parkinson disease, will need in the future an integrated vision of all mitochondrial aspects from emerging methods to evaluate mitochondria function to new molecular interactions link to this organelle. By this way, the 7th World Congress on Targeting Mitochondria was, for me, a huge success by connecting remarkable researchers from such different area of the field, For these reasons, it will be a great pleasure for me to participate to this conference next year."

 

The second award was discerned to François Mouton-Liger from the ICM - Brain & Spine Institute, France for his short oral presentation about "Role of Parkin in innate immunity: crosstalk between mitochondrial dysfunction and NLRP3 inflammasome signaling".

For more information about this award, please click here.

World Mitochondria Society

Organize a meeting with the leaders in mitochondria field

Targeting-Mitochondria-Network-SessionTargeting Mitochondria attendees, academics and industrials, are invited to a warm-up networking session over the lunch and coffee breaks. Already more than 300 registrants!

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