Neurodegeneration and Mitochondria

Mitochondria-Speakers-Ming-Guo

Prof. Ming Guo from UCLA David Geffen School of Medicine, USA will join the Targeting Mitochondria 2020 Congress which will be held in Berlin, Germany on October 29-30, 2020 and present her research during the talk entitled "Neurodegeneration and Mitochondria".

Summary of the Talk: Mitochondrial dysfunction has emerged as a common shared mechanism across multiple neurodegenerative disorders. This includes Parkinson’s disease, myopathy/frontotemporal dementia and ALS. The talk will discuss the latest research regarding these areas. 

 Targeting Mitochondria 2020 Congress
October 29-30, 2020 - Berlin, Germany
www.mitochondria-site.com

Mitochondrial Dysfunction in Autism is Distinct from Mitochondrial Disease

Mitochondria-Speakers-Richard-E.-Frye-v1The Organizing Committee of Targeting Mitochondria 2020 is honored to announce the participation of Prof. Richard E. Frye from Phoenix Children's Hospital, USA.

During the congress, Prof. Frye will give a strategic talk entitled "Mitochondrial Dysfunction in Autism is Distinct from Mitochondrial Disease".

Summary of the talk: Several lines of evidence suggest that mitochondrial function is not normal in many individuals with Autism Spectrum Disorder. However, the patterns of abnormalities found are unlike those seen in classic mitochondrial disease and include unique changes in electron transport chain activity, fatty acid metabolism and regulation of oxidative stress. This talk presents data that suggest that these unique abnormalities are a product of long-term metaplasticity adaptations resulting from exposure to extrinsic or intrinsic physiological stressors such as environmental exposures, microbiome alterations, nutrient deficiencies and/or inflammatory events.

 

Targeting Mitochondria 2020 Congress
October 29-30, 2020 - Berlin, Germany
www.mitochondria-site.com

Off-target effects of mitochondria-targeted compounds

Mitochondria Speakers Werner-KoopmanProf. Werner Koopman from RadboudUMC University, The Netherlands will join the 11th World Congress on Targeting Mitochondria 2020 Congress.

Prof. Koopman will give a presentation entitled "Off-target effects of mitochondria-targeted compounds" during the congress.

 

Targeting Mitochondria 2020 Congress
October 29-30, 2020 - Berlin, Germany
www.mitochondria-site.com

Down Syndrome: Role of hydrogen sulfide overproduction in the pathogenesis of mitochondrial dysfunction

Mitochondria Speakers Csaba SzaboThe Organizing Committee of Targeting Mitochondria 2020 honored to welcome Prof. Csaba Szabo from the Université de Fribourg, Switzerland.

Prof. Szabo will give a talk entitled "Down Syndrome: Role of hydrogen sulfide overproduction in the pathogenesis of mitochondrial dysfunction" during the congress which will be held on October 29-30, 2020 in Berlin, Germany.

Summary of the talk:  Cystathionine-β-synthase (CBS) is one of the key mammalian enzymes that is responsible for the biological production of the gaseous transmitter hydrogen sulfide (H2S). When H2S is overproduced, it can exert detrimental cellular effects, in part due to inhibition of mitochondrial Complex IV activity. An increased expression of CBS and the consequent overproduction of H2S is well documented in individuals with Down syndrome (DS). Two decades ago, it has been proposed that a toxic overproduction of H2S importantly contributes to the metabolic and neurological deficits associated with DS. However, until recently, this hypothesis has not yet been tested experimentally. The present talk will present recent data generated in human dermal fibroblasts showing that DS cells overproduce H2S, which, in turn, suppresses mitochondrial Complex IV activity and impairs mitochondrial oxygen consumption and ATP generation. Therapeutic CBS inhibition lifts the tonic (and reversible) suppression of Complex IV: this results in the improvement of mitochondrial function in DS cells.

 

Targeting Mitochondria 2020 Congress
October 29-30, 2020 - Berlin, Germany
www.mitochondria-site.com

Submit your Best Mitochondria Image for selection and Win...

BEST-IMAGESSubmit a memorable Mitochondria image you’ve taken this past year and be entered into a drawing for 3 prizes : 

 

- First: 2 nights hotel and free registration at Targeting Mitochondria Meeting in Berlin

- Second: Free Registration 

- Third: One Dinner 
 

Entries must be original. We also accept all Artworks and drawing related to Mitochondria (life, death, energy, dynamics and philosophy...)

 

By submitting your image and caption, you give the WMS permission to include your image (with proper credit being given) into our  2nd edition of MiMB “Mitochondrial Medicine”.

 

To submit, please send us your Mitochondria image + Name and Affiliation to This email address is being protected from spambots. You need JavaScript enabled to view it.

 

 

Prof. Carsten Culmsee, Magburg University, Germany, awarded by the World Mitochondria Society

 Prof. Carsten Culmsee

World MitochondriSociety is honored to announce the winner of the award for his exceptional scientific contribution for the year 2019, Prof. Carsten Culmsee,  from the Magburg University, Germany. 

Prof. Culmsee gave an excellent communication during the 10th World Congress on Targeting Mitochondria 2019, which was held in Berlin, Germany, about the role of actin-regulating proteins on mitochondria

During Targeting Mitochondria 2019, Prof. Culmsee presented new data on the key role of actin-regulating proteins on mitochondrial integrity and function in health and disease of the nervous system and the heart. Also, his talk shows an involvement of mitochondria damage in iron-dependent regulated oxidative cell death called ferroptosis that has been identified in several different organs and tissues, including the nervous system. 

 Carsten Culmsee

For media information: 
Media center: World Mitochondria Society
Contact: www.targeting-mitochondria.com

Keynote Presentation by Prof. Wallace: A Mitochondrial Etiology of the Common Complex Diseases

Prof. Doug Wallace Targeting mitochondria 2019

The Organizing Committee of Targeting Mitochondria 2019 congress is honoured to announce that Prof. Douglas Wallace will be joining us for our 10th Anniversary Edition of Targeting Mitochondria World Congress, which will be held in Berlin on October 28th-29th, 2019.

Prof. Douglas Wallace, Member of the National Academy of Science since 1995, is Professor of Pediatrics, Division of Human Genetics, at the University of Pennsylvania and the founding director of the Center for Mitochondrial and Epigenomic Medicine at the Children's Hospital of Philadelphia. Over the past 45 years Wallace has introduced mitochondrial DNA (mtDNA) genetics into medicine thus founding the field of Mitochondrial Genetic Medicine. In 1975, Wallace and associates showed that genetic factors could be inherited though the cytoplasm with the cytoplasmic transfer of chloramphenicol resistance. In 1980 he demonstrated that the human mtDNA is maternally inherited and in 1988 he was the first to identify an inherited human mtDNA disease, Leber hereditary optic neuropathy (LHON). Since then hundreds of mtDNA variants have been linked to disease, see MITOMAP.org. By surveying mtDNA variation in indigenous populations around the world, Wallace and his associates were able to exploit the maternal transmission of the mtDNA to reconstruct the origin and ancient migrations of women. Subsequent studies revealed that the geographic specificity of mtDNA types was the result of environmental selection and that these “adaptive” mtDNA variants can become maladaptive in new environments generating the common variants of common diseases.

At our 10th Anniversary World Congress on Targeting Mitochondria Prof. Wallace will give a Keynote Presentation titled “A Mitochondrial Etiology of the Common Complex Diseases”.

For more information about Targeting Mitochondria 2019: https://targeting-mitochondria.com

Targeting Mitochondria 2019 Congress : Information / Venue / Final Agenda

Please find here all the practical information concerning the Targeting Mitochondria 2019 Congress.

1) Badges & material delivery

The organizing committee will distribute badge and materials Sunday on October 27th, from 17pm to 18:00pm and Monday on October 28th from 7:45 am in the lobby of the Pavillon meeting room.

2) Conference venue

The Congress will be held in the Pavillon meeting room. 

at the InterContinental Berlin Hotel
Budapester Straße 2, 10787 Berlin, Germany
 
If you want to know how to reach the Hotel from Berlin Airport, click here

3) Targeting Mitochondria 2019 Congress Dinner

A dinner is organized on Monday, October 27 at InterContinental Hotel Berlin at 8:30 PM.
If you are not yet registered, Please register here.

4) Who is attending and Networking

In order to organize your planning & meeting with attendees, please find here the list universities and industrials on the site.

5) Certificate of Attendance


The certificate of attendance will be sent to all attendees by email after the Congress.

For all information about activities in Berlin during your stay, please visit the Berlin tourist office here.

6) Final Agenda 

The scientific committee published the final Agenda of Targeting Mitochondria 2019 Congress.


We look forward to meeting you in Berlin and please don't hesitate to contact us for further information.


Targeting-Mitochondria-2019-final-agenda-small

Scientific Agenda

 

Register-here-small

The Short Oral Contribution was discerned to Dr. Jana Schulz

Jana Schulz 1
The Short Oral Contribution Award was discerned to Dr. Jana Schulz from Max Delbrück Center in the Helmholtz Association (MDC), Berlin, Germany, during Targeting Mitochondria 2019, which was held in Berlin, Germany, for her excellent oral presentation entitled "A catalogue of novel mitochondrial microproteins in the human heart".

The presentation of Dr. Schulz concluded that many cardiac long noncoding RNAs (IncRNAs) produce small proteins in vivo and a compelling fraction of which can be associated with the mitochondrion by computational and experimental analyses.

Jana Schulz 2

Jana Schulz

For media information
Media center: World Mitochondria Society
Contact: www.targeting-mitochondria.com

A review paper published by Prof. Weissig, president of the World Mitochondria Society

We are pleased to announce that the review paper of Prof. Weissig, president of WMS, about drug development for mitochondrial diseases, has been recently published online in Trends in Moleculaire Medicine.

Weissig Picture Review

We congratulate Prof. Weissig for his excellent review. 

For more information and access to the review: 
Drug Development for the Therapy of Mitochondrial Diseases
Weissig V. 
Trends Mol Med. 2019, Nov 11
doi.org/10.1016/j.molmed.2019.09.002

"Beautiful anomaly" by Sonja Lehmann

"Beautiful anomaly", submitted by Sonja Lehmann, from the Intitute of Molecular and Cellular Anatomy, in Aachen, Germany, is the second image selected by the Scientific Committee of Targeting Mitochondria 2019 for the 10th anniversary.

4 PC-Keratinocyte MitoTimer SonjaLehmann

Immortalized human keratinocytes derived from patients with the hereditary skin disease Pachyonychia congenita were transfected with MitoTimer. Confocal live-cell imaging revealed the bizarre mitochondrial morphology that rarely occurs in atypical cells.

"Kissing nano-tunnels" by Patricia Morcillo

"Kissing nano-tunnels" is a beautiful image submitted to the World Mitochondria Society by Patricia Morcillo, from Albert Einstein College of Medicine, in New York, USA, and selected by the Scientific Committee for the 10th anniversary of Targeting Mitochondria congress. 

10 Kissing nanotunnels

As described by Patricia Morcillo, mitochondrial communication is lost after exposure to manganese-induced Parkinsonism.

A honor for Targeting Mitochondria 2019 to welcome Prof. Douglas Wallace

It was a great honor to welcome Prof. Douglas Wallace, Member of the National Academy of Science since 1995, during Targeting Mitochondria 2019, for his excellent talk entitled "A Mitochondrial Etiology of the Common Complex Diseases". 
The World Mitochondria Society would like to thank Prof. Wallace for his participation. 

Prof.Wallace-4

Prof.Wallace-3

For media information 
Media center: World
Mitochondria Society 
Contact: www.targeting-mitochondria.com

World Mitochondria Society would like to thank Biolog

World Mitochondria Society Team would like to thank Biolog for their support and participation during Targeting Mitochondria 2019, which was held in Berlin, Germany in October. 

 

Biolog Mitoplates tm Logo 2

 

Biolog had a booth during the two days of conference, and a talk presented by Dr. Barry R. Bochner from Biolog on their news assays plates, the MitoPlate I-1TM, which has a triplicate repeat of 30 energy producing substrates and the MitoPlate S-1TM, which has 22 inhibitors of mitochondrial function titrated at 4 dilutions. Using these new assays Dr. Bochner shows that mitochondria from different cell types exhibit different functional properties.

Biolog-4

Biolog-6

Biolog-5

For media information 
Media center: World Mitochondria Society 
Contact: www.targeting-mitochondria.com

The organizers of Targeting Mitochondria 2019 would like to thank MitoQ

The organizers thank MitoQ for their support and participation at the Targeting Mitochondria 2019. 

MitoQ-Targeting-Mitochondria-Sponsor

 

MitoQ also supports the presentation of Prof. Douglas Seals, from the University of Colorado Boulder, USA, on the mitochondria antioxidant therapy for treating vascular aging.  

Prof. Seals

Prof. Seals-4

For media information 
Media center: World Mitochondria Society 
Contact: www.targeting-mitochondria.com