Comprehensive Multi-Omics Analysis Reveals Mitochondrial Stress as a Central Biological Hub for Spaceflight Impact

Afshin BeheshtiDr. Afshin Beheshti, from the NASA Ames Research Center, Moffett Field, USA will join us this year to present his recent findings on "Comprehensive Multi-Omics Analysis Reveals Mitochondrial Stress as a Central Biological Hub for Spaceflight Impact".

Targeting Mitochondria 2021 Congress
October 27-29, 2021 - Berlin & Virtual Congress
www.targeting-mitochondria.com

 

 

 

Programmable Synthetic Gene Switches for Mitochondrial Gene Modulation

Targeting Mitochondria 2021 Ganesh-Pandian-NamasivayamProf. Ganesh Pandian Namasivayam from Kyoto University, Institute for Advanced Study, Japan, will join the Targeting Mitochondria 2021 congress and will present his research on "Deleting DNA to Treat Mitochondrial Diseases".

According to his latest studies, mutations in mitochondrial DNA (mtDNA) cause mitochondrial diseases characterized by abnormal mitochondrial function. Although eliminating mutated mtDNA has the potential to cure mitochondrial diseases, no chemical-based drugs in clinical trials are capable of selective modulation of mtDNA mutations. In his presentation, Prof. Ganesh discusses the progress and therapeutic prospects of  synthetic gene switches that can be programmed for targeted elimination of mutated mtDNA through sequence-specific adenine alkylation.

 

Targeting Mitochondria 2021 Congress
October 27-29, 2021 - Berlin & Virtual Congress
www.targeting-mitochondria.com

The Mitochondriotropic DecylTPP Group Lowers Mitochondrial OXPHOS Supercomplex Levels and Induces a Glycolytic Switch

Werner KoopmanProf. Werner Koopman, from the Department of Biochemistry, Radboud Institute for Molecular Life Sciences, will join the Targeting Mitochondria 2021 Congress and will present a talk entitled "The Mitochondriotropic DecylTPP Group Lowers Mitochondrial OXPHOS Supercomplex Levels and Induces a Glycolytic Switch".

Prof. Koopman will discuss the bioenergetic effects of mitochondria-targeted Trolox(MitoE10), in comparison with mitochondria-targeted ubiquinone (MitoQ10) and two mitochondria-targeting moieties (decylTPP, TPMP). Incubation with these molecules did not greatly affect cell viability of primary human skin fibroblasts (PHSFs) from healthy individuals and a patient with Leigh Syndrome (LS). Unexpectedly, MitoE10, MitoQ10 and decylTPP reduced the levels and activity of the first oxidative phosphorylation complex (complex I or CI) and of the amount of  CI+CIII-containing OXPHOS super complexes. Functionally, these effects were associated with reduced cellular oxygen consumption rates, increased extracellular acidification rates , a less negative mitochondrial membrane potential (deltaPSI), a decreased mitochondrial size and elevated levels of hydroethidine-oxidizing ROS. Collectively, these results demonstrate that MitoE10, MitoQ10 and decylTPP lower the levels of CI and CI-containing super complexes in PHSFs, leading to mitochondrial dysfunction and glycolytic switch induction.

Targeting Microbiota 2021 Congress
October 20-22, 2021 - Paris, France & Online
www.targeting-mitochondria.com

The One-Carbon Pool Controls Mitochondrial Energy Metabolism via Complex I and Iron-Sulfur Clusters

Anna Wredenberg

Dr. Anna Wredenberg, from Max Planck Institute Biology of Ageing–Karolinska Institutet Laboratory, Karolinska Institutet, Sweden will be joining the Targeting Mitochondria 2021 World Congress, and will deliver a speech concerning "The One-Carbon Pool Controls Mitochondrial Energy Metabolism via Complex I and Iron-Sulfur Clusters".

Accoring to her recent studies, Dr. Wredenberg confirms that vital intermediary steps of one-carbon metabolism are localized to mitochondria, but it remains unclear how it connects to mitochondrial function. Additionally,The one-carbon metabolite and methyl group donor S-adenosylmethionine (SAM) is pivotal for energy metabolism. A gradual decline in mitochondrial SAM (mitoSAM) causes hierarchical defects in fly and mouse, comprising loss of mitoSAM-dependent metabolites and impaired assembly of the oxidative phosphorylation system. Complex I stability and iron-sulfur cluster biosynthesis are directly controlled by mitoSAM levels, while other protein targets are predominantly methylated outside of the organelle before import.

However, the mitoSAM pool follows its cytosolic production, establishing mitochondria as responsive receivers of one-carbon units.

 

Targeting Mitochondria 2021 Congress
October 27-29, 2021 - Berlin & Virtual Congress
www.targeting-mitochondria.com

Dysregulation of Mitochondria-Lysosome Contacts by GBA1 Dysfunction in Dopaminergic Neuronal Models of Parkinson’s Disease

Dimitri-Krainc

Dr. Dimitri Krainc, from the Northwestern University Feinberg School of Medicine, Chicago in USA will be will be joining the Targeting Mitochondria 2021 Congress and will demonstrate his study regarding the "Dysregulation of Mitochondria-Lysosome Contacts by GBA1 Dysfunction in Dopaminergic Neuronal Models of Parkinson’s Disease".

Dr. Krainc confirms that he recently identified the formation of direct mitochondria-lysosome membrane contacts that mark sites for lysosomal regulation of mitochondrial networks. However, mitochondrial contacts regulate lysosomal dynamics providing a new angle to studies of these organelles in neurodegenerative diseases.

 

Targeting Mitochondria 2021 Congress
October 27-29, 2021 - Berlin & Virtual Congress
www.targeting-mitochondria.com

Introduction Remarks: Past, Present and Future

Egbert MikDr. Egbert Mik, from University Medical Center Rotterdam, The Netherlands, will join the 12th Targeting Mitochondria Congress in October 2021, to give a talk entitled "Introduction Remarks: Past, Present and Future". 

During the sessin, Dr. Mik will explain the challenge of qualitative and quantitative assessment of mitochondrial function in vitro and in vivo, as well as future perspectives regarding this subject.

 

 

Targeting Mitochondria 2021 Congress
October 27-29, 2021 - Berlin & Virtual Congress
www.targeting-mitochondria.com

 

A Potential Mitochondrial Link Between Life Stress and the Reversibility of Hair Greying in Humans

Targeting Mitochondria 2021 Marin PicardDrMartin PicardAssociate professor of behavioral medicine at Columbia University Vagelos College of Physicians and Surgeons, USA will be joining the Targeting Mitochondria 2021 Congress and give a presentation entitled "A Potential Mitochondrial Link Between Life Stress and the Reversibility of Hair Greying in Humans".

Life stress causes neuroendocrine and metabolic alterations that influence mitochondria; and in turn, mitochondria produce signals and energy that influence pigment production that color our hairs. This presentation will describe a new approach to quantify human hair pigmentation patterns, demonstrating that human hair graying is rapidly reversible and linked to life stress. Individual hairs transitioning from their young-dark to old-white states, and reverting back to dark, show specific mitochondrial proteomic recalibrations pointing to a threshold-based metabolic mechanism for hair greying.

Targeting Mitochondria 2021 Congress
October 27-29, 2021 - Berlin & Virtual Congress
www.targeting-mitochondria.com

Optimization of Energy Homeostasis in Old Age by SIRT6

Targeting Mitochondria 2021 Haim-CohenProf. Haim Cohen, head of the Molecular Mechanism of Aging Laboratory at Bar-Ilan University, Israel will be joining the Targeting Mitochondria 2021 Congress and give a presentation entitled "Optimization of Energy Homeostasis in Old Age by SIRT6".

Prof. Cohen's Studies in model organisms showed that the activity of the Sir2 family of NAD+-dependent protein deacetylases (sirtuins) is important in regulating lifespan in yeast, worms, and flies. He shows that overexpression of mammalian sirtuin SIRT6 in mice leads to a reduction in frailty and lifespan extension by ~30%. To do so, SIRT6 restores energy homeostasis of old animals through an improvement in the utilization of two major gluconeogenic precursors, lactate and glycerol.

Targeting Mitochondria 2021 Congress
October 27-29, 2021 - Berlin & Virtual Congress
www.targeting-mitochondria.com

 

 

Nuclear Sensing of Breaks in Mitochondrial DNA Enhances Immune Surveillance

Targeting Mitochondria 2021 sfeir-agnelDr. Agnel Sfeir from Memorial Sloan Kettering Cancer Center, USAwill give a presentation on :Nuclear Sensing of Breaks in Mitochondrial DNA Enhances Immune Surveillance"

Dr. Sfeir will describe mitochondrial DNA double-strand breaks (mtDSBs) as toxic lesions that compromise the integrity of mitochondrial DNA (mtDNA) and alter mitochondrial function. Communication between mitochondria and the nucleus is essential to maintain cellular homeostasis; however, the nuclear response to mtDSBs remains unknown. Here, using mitochondrial-targeted transcription activator-like effector nucleases (TALENs), we show that mtDSBs activate a type-I interferon response that involves the phosphorylation of STAT1 and activation of interferon-stimulated genes. After the formation of breaks in the mtDNA, herniation mediated by BAX and BAK releases mitochondrial RNA into the cytoplasm and triggers a RIG-I-MAVS-dependent immune response. We further investigated the effect of mtDSBs on interferon signalling after treatment with ionizing radiation and found a reduction in the activation of interferon-stimulated genes when cells that lack mtDNA are exposed to gamma irradiation. We also show that mtDNA breaks synergize with nuclear DNA damage to mount a robust cellular immune response. Taken together, we conclude that cytoplasmic accumulation of mitochondrial RNA is an intrinsic immune surveillance mechanism for cells to cope with mtDSBs, including breaks produced by genotoxic agents.

 

Targeting Mitochondria 2021 Congress
October 27-29, 2021 - Berlin & Virtual Congress
www.targeting-mitochondria.com

 

Impact of Mitochondrial Dynamics on Stem Cell Function: Insights from Physiology, Diseases and Aging

mireille

Dr. Mireille Khacho, from Faculty of Medicine, University of Ottawa, Canada will be joining the Targeting Mitochondria 2021 World Congress, which will be held October 27-29, 2021 and will present her study on "The Impact of Mitochondrial Dynamics on Stem Cell Function: Insights from Physiology, Diseases and Aging".

 

 

 

Targeting Mitochondria 2021 Congress
October 27-29, 2021 - Berlin & Virtual Congress
www.targeting-mitochondria.com

 

Age-Related Mitochondrial Dysfunction as a Key Factor in COVID-19 Disease

miDr. Guillermo López-Lluch from Universidad Pablo de Olavide-CSIC, Spain will be joining the Targeting Mitochondria 2021 World Congress, which will be held October 27-29, 2021 and give a presentation on Age-related Mitochondrial Dysfunction as a Key Factor in COVID-19 Disease.

Dr. Lluch states that COVID-19 and other respiratory diseases induce an inflammatory response mainly produced by the release of inflammatory cytokines. In this response, lymphocyte release of interferon decrease impairing the immune response against virus infection. In both, inflammatory response and inhibition of interferon release, activity of mitochondria plays a key role. Accumulation of dysfunctional mitochondria during aging and chronic metabolic diseases can be the key of the inefficient response against respiratory infections.

 

Targeting Mitochondria 2021 Congress
October 27-29, 2021 - Berlin & Virtual Congress
www.targeting-mitochondria.com

 

 

Clinical Application of Antioxidants to Improve Human Oocyte Mitochondrial Function: Advances and Perspective

MitoDr. Cristina Rodríguez-Varela from Medical Research Institute Hospital La Fe (IIS La Fe) in Valencia, Spain will give a presentation on Clinical Application of Antioxidants to Improve Human Oocyte Mitochondrial Function: Advances and Perspective.

Dr. Rodríguez-Varela will discuss the fact that mitochondria are essential organelles in the acquisition of human oocyte competence, as sufficient energy levels are crucial for optimal oocyte maturation, fertilization and subsequent embryo development. In addition, mitochondria constitute the first antioxidant line of defense within the cell, counteracting reactive oxygen species (ROS) derived from its own metabolism. An imbalance between the amount of ROS produced and the capacity of the cell to counteract them leads to oxidative stress, and ultimately to mitochondrial dysfunction. This dysfunction, in turn, impairs cellular functions through reduced ATP output and/or increased oxidative stress. Hence, oxidative stress may be the cause of, or be caused by, mitochondrial dysfunction. Regardless of the origin, this condition gives rise to a vicious cycle with positive feedback, ultimately compromising the overall oocyte quality. Antioxidant therapy has arisen in this context as a new approach aiming to improve human oocyte quality by means of improving, or just protecting, mitochondrial function. In this talk, we will highlight the importance of optimal levels of functional mitochondria in the acquisition of human oocyte competence, and we will give an overview of the main antioxidant supplementation therapies currently under research in our species.

 

Targeting Mitochondria 2021 Congress
October 27-29, 2021 - Berlin & Virtual Congress
www.targeting-mitochondria.com

Extracellular Mitochondria for Therapy and Diagnosis in Stroke

Targeting Mitochondria 2021 Kazuhide Hayakawa-v2

Dr. Kazuhide Hayakawa, Assistant Professor at Harvard Medical School/ Massachusetts General Hospital, USA will join the Targeting Mitochondria 2021 congress which will be held on October 27-29, 2021 and give a presentation entitle "Extracellular Mitochondria for Therapy and Diagnosis in Stroke".

Recent accumulating findings in cell were provided by Dr. Hayakawa, as well as in animals and humans. These studies suggest that mitochondria maybe surprisingly present in extracellular space andregulatea non-cell-autonomous mechanism in the CNS by mediating injury and recovery. Given that extracellular mitochondria are passively secreted by damaged cells or released from activated cells, it may allow us to look into the metabolic status to diagnose overall disease severity or progress of repair. Moreover, exogenous mitochondrial transplantation may protect neurons in acute CNS injury. Further studies are warranted to carefully assess whether extracellular mitochondria serve as a novel class of biomarkers and whether the putative transfer of mitochondria between cells in the CNS can be leveraged to augment recovery after stroke or neurodegenerative diseases.

 

Targeting Mitochondria 2021 Congress
October 27-29, 2021 - Berlin & Virtual Congress
www.targeting-mitochondria.com

Big Change from Small Player - Mitochondria Alter Body Metabolism and Gene Expression

Targeting Mitochondria 2021 Scott Balinger-V5Prof. Scott Ballinger from University of Alabama at Birmingham, USA will be joining the Targeting Mitochondria 2021 World Congress, which will be held October 27-29, 2021 and give a presentation on "Big Change from Small Player - Mitochondria Alter Body Metabolism and Gene Expression".

 

 

 

Targeting Mitochondria 2021 Congress
October 27-29, 2021 - Berlin & Virtual Congress
www.targeting-mitochondria.com

Mitochondrial Transplantation Therapy, the Recent Advances and Perspective

Targeting Mitochondria 2021 James McCullyDr. James McCully, from the Harvard Medical School Department of Cardiac Surgery Boston Children’s Hospital, USA, will be joining the Targeting Mitochondria 2021 World Congress, which will be held October 27-29, 2021.

Dr. McCully will present his recent study on "Mitochondrial Transplantation Therapy, the Recent Advances and Perspective" during the congress.

Dr. McCully’s research focuses on the mechanisms and subcellular localization of the biochemical and molecular events contributing to myocardial cell death. In particular, his lab has investigated the discriminant and/or coordinate mechanisms leading to ischemia/reperfusion injury in the neonate, child, mature and aged male and female with particular emphasis on the development of novel and specific cardioprotective protocols. 

Recently he has developed a novel approach to cardioprotection using autologous mitochondrial transplantation. His research has demonstrated that transplantation of autogeneic mitochondria into the ischemic zone of the myocardium during early reperfusion significantly enhances post-ischemic functional recovery.

Targeting Mitochondria 2021 Congress
October 27-29, 2021 - Berlin & Virtual Congress
www.targeting-mitochondria.com