Patient-Specific Brain Organoids for modeling Mitochondrial Diseases

Targeting mitochondria 2021 Alessandro Prigione

We are honored to announce the participation of Prof. Alessandro Prigione from, Heinrich Heine University (HHU), Germany, at Targeting Mitochondria 2021 congress.

Prof. Prigione will talk about "Patient-Specific Brain Organoids for modeling Mitochondrial Diseases" during the congress which will be held on October 27-29, 2021 in Berlin & Online.

Summary of talk: Mitochondrial diseases suffer from a lack of effective animal and cellular models. This hampers our understanding of the mechanisms underlying the neuronal pathology characteristics of mitochondrial diseases. We used patient-derived induced pluripotent stem cells (iPSCs) and genome engineering with CRISPR/Cas9 to develop a human model of Leigh syndrome, which is the most severe mitochondrial disease in children and is currently incurable. Using neuronal cell cultures and three-dimensional brain organoids, we discovered previously unknown mechanisms causing the disease-specific neuronal defects, and identified two potential counteracting strategies for this rare mitochondrial disease with highly unmet medical need.

For more information about the article: https://www.nature.com/articles/s41467-021-22117-z

Targeting Mitochondria 2021 Congress
October 27-29, 2021
Berlin, Germany & Virtual Congress
www.targeting-mitochondria.com