Regulation of Physiological Mitophagy

Targeting Mitochondria 2021 Dr. Thomas McWilliamsProf. Thomas G. McWilliams from University of Helsinki, Finland will join the Targeting Mitochondria 2021 congress and will present his research on Regulation of Physiological Mitophagy.

Summary of talk: Mitochondrial network dysfunction is neutralised by the selective autophagy of mitochondria (mitophagy). Mitophagy is widely thought to be a disease-relevant process and is routinely implicated in neurodegenerative pathology and mammalian aging. Yet, most of our knowledge and assumptions about mitophagy are derived from its induction as a PINK1-Parkin-dependent stress-responsein vitro. Converging data from multiple mitophagy reporter models suggests that this process is much more complex in tissues than previously appreciated. Mitophagy is a highly pervasive and heterogeneous processin vivo, that proceeds normally in the absence of the PINK1-Parkin signalling pathway. Using a multi-OMICs approach, we have defined the progression and regulation of PINK1-independent mitophagy, deciphering its integration with other homeostatic pathways to safeguard cellular and metabolic integrity.

Key Publications

McWilliams TG*,Prescott AR, Montava-Garriga L, Brooks SP, Singh F, Barini E, Muqit MM and Ganley IG*(2018a)
Basal mitophagy occurs independently of PINK1 in mouse tissues of high-metabolic demand. Cell Metabolism Feb 06; 27(2): 439-449. 

McWilliams TG* et al., (+28 Authors) Ganley IG, Suomalainen A, Muqit MMK*(2018b).
Phosphorylation of Parkin at Serine65 is essential for its activation in vivo.
Open Biology. Nov8:180108. 

Suomi F & McWilliams TG*(2019)
Autophagy in the nervous system: a primer for neuroscientists.
Neuronal Signaling 3 (3): NS20180134.

Targeting Mitochondria 2021 Congress
October 27-29, 2021 - Berlin & Virtual Congress